Acetone Cyanohydrin → 2-((4-Hydroxybutyl)amino)-2-methylpropanenitrile

HRID 35945

Reaction equation

HRID 35945 reaction equation
[CH3:1][C:2]([CH3:6])(O)[C:3]#[N:4].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>C(Cl)Cl>[OH:12][CH2:11][CH2:10][CH2:9][CH2:8][NH:7][C:2]([CH3:6])([CH3:1])[C:3]#[N:4]

Participants

4

Reactant 2

HCID 6406Acetone CyanohydrinHCID 258684-Amino-1-butanol

Product 1

HCID 155119612-((4-Hydroxybutyl)amino)-2-methylpropanenitrile

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

220 μl of acetone cyanohydrin and 200 μl of 4-amino 1-butanol were mixed together with stirring for 16 hours at 20° C. and then was diluted with 2 ml of methylene chloride, dried, filtered and the filtrate was concentrated under reduced pressure to obtain the propanonitrile which was used as is for the following stage.

Workup

  1. customdried
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-af507ea0ea16417b8b65e6f6abd9ae52
Source dataset
uspto-grants-1995_05
Patent number
US05411981

Linked notes

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