Reaction equation
[Cl:1][C:2]1[CH:20]=[C:19]([C:21]2[O:22][CH2:23][CH2:24][N:25]=2)[CH:18]=[C:17]([Cl:26])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([CH2:15][OH:16])[CH:11]=1.[C:27]([O:30][CH2:31][CH2:32][O:33][CH2:34]Br)(=[O:29])[CH3:28].[H-].[Na+]>>[C:27]([O:30][CH2:31][CH2:32][O:33][CH2:34][O:16][CH2:15][C:12]1[CH:11]=[C:10]([CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][O:4][C:3]2[C:2]([Cl:1])=[CH:20][C:19]([C:21]3[O:22][CH2:23][CH2:24][N:25]=3)=[CH:18][C:17]=2[Cl:26])[O:14][N:13]=1)(=[O:29])[CH3:28]Participants
4
Procedure
5-{5-[2,6-Dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]-pentyl}-3-isoxazolylmethoxymethoxyethyl acetate [XXIV; n=5, R1 and R2 =Cl] was prepared from 4.0 g of 5-{5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-isoxazolemethanol (Example 116) and 2.0 g of 2-acetoxyethoxymethyl bromide [CH3COCH2CH2OCH2Br] in the presence of sodium hydride according to the procedure of Example 117, and was obtained in the form of a colorless oil (2.4 g).
Sources & evidence
- ORD record
- ord-169c92551881403cbcb80b9daeb530c0
- Source dataset
- uspto-grants-1991_03
- Patent number
- US05002960
Linked notes
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