Acetic Acid → Dimethyl dicarbonate

Reaction equation

[C:1]([OH:13])(=[O:12])CC(CC(O)=O)(C(O)=O)O.[C:14]([OH:21])(=[O:20])/C=C\C(O)=O.C(O)(=O)[CH:23](C(C(O)=O)O)[OH:24].[C:32](O)(=O)C>>[CH3:23][O:24][C:14]([O:21][C:1]([O:13][CH3:32])=[O:12])=[O:20]

Participants

Reactant 4

HCID 176Acetic Acid

HCID 311Citric Acid

HCID 8752,3-Dihydroxybutanedioic Acid

HCID 444266Maleic Acid

Product 1

HCID 3086Dimethyl dicarbonate

Procedure

To each pharmaceutical composition (500 mg) of DMDC 2H2O packed in vials or ampoules in Examples 3 to 8 was added 10 ml of 1 w/v % aqueous lactic acid for dissolution to give injections of DMDC 2H2O. The same procedure was repeated using 3 w/v % aqueous citric acid, 5 w/v % aqueous maleic acid, 6 w/v % aqueous tartaric acid or 10 w/v % aqueous acetic acid to give injections of DMDC 2H2O.