Ethyl Acetoacetate → 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-(4-nitrophenyl)-

HRID 362448

Reaction equation

HRID 362448 reaction equation
Cl.[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][NH2:12])=[CH:7][CH:6]=1)([O-:4])=[O:3].[C:13](OCC)(=[O:18])[CH2:14][C:15]([CH3:17])=O>C(O)C>[CH3:17][C:15]1[CH2:14][C:13](=[O:18])[N:11]([C:8]2[CH:7]=[CH:6][C:5]([N+:2]([O-:4])=[O:3])=[CH:10][CH:9]=2)[N:12]=1

Participants

4

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 54634014-Nitrophenylhydrazine hydrochloride

Product 1

HCID 808163H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-(4-nitrophenyl)-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.63 g of p-nitrophenylhydrazine hydrochloride and 1.26 g of ethyl acetoacetate are heated under reflux in 30 ml of ethanol for 45 min. The mixture is concentrated somewhat in vacuo. The crystals which have separated out are then filtered off with suction.

Workup

  1. concentrationThe mixture is concentrated somewhat in vacuo
  2. customThe crystals which have separated out
  3. filtrationare then filtered off with suction

Sources & evidence

ORD record
ord-9708b4ea09704412845a368f792b6756
Source dataset
uspto-grants-1999_02
Patent number
US05869516

Linked notes

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