N-Methylbutylamine → N-butyl-N-methylacetamide dimethyl acetal

Reaction equation

[CH2:1](NC)[CH2:2][CH2:3]C.[CH3:7][O:8][C:9]([O:14][CH3:15])([N:11]([CH3:13])[CH3:12])[CH3:10]>>[CH3:7][O:8][C:9]([O:14][CH3:15])([N:11]([CH2:13][CH2:1][CH2:2][CH3:3])[CH3:12])[CH3:10]

Participants

Reactant 2

HCID 8068N-Methylbutylamine

HCID 878351,1-Dimethoxyethyl(dimethyl)amine

Product 1

HCID 19379602N-butyl-N-methylacetamide dimethyl acetal

Conditions

Temperature: 130 °C

Procedure

6.1 g (0.07 mol) of n-butylmethylamine are stirred with 9.3 g (0.07 mol) of N,N-dimethylacetamide dimethyl acetal for 24 hours under reflux at a bath temperature of 130° C. Subsequent vacuum distillation gives N-butyl-N-methylacetamide dimethyl acetal, bp 72°-75° C./31 mbar.

Workup

distillationSubsequent vacuum distillation

Sources & evidence

ORD record: ord-958d91a3e3b94844878d9825f3955bb5
Source dataset: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05413994

Reaction notes

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