Phenol → 2-Naphthyloxy proline amide
Reaction equation
FC(F)(F)C(O)=O.C([NH:12][C:13](=[O:26])[C@@H:14]1[CH2:18][C@H:17](OC2C=CC=CC=2)[CH2:16][NH:15]1)(C)(C)C.[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1[OH:37].C1(O)C=CC=CC=1>>[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1[O:37][N:15]1[CH2:16][CH2:17][CH2:18][C@H:14]1[C:13]([NH2:12])=[O:26]Participants
4
Procedure
Following substantially the same procedure for synthesizing N-t-butyl-4(S)-phenoxy-L-prolineamide trifluoroacetic acid salt as outlined in Example 1, Steps 6 through 8, but substituting 2-naphthol for the phenol used therein, the 2-naphthyloxy proline amide was produced.
Sources & evidence
- ORD record
- ord-0eeef0b37a0e4d0fb70dd3356eb3ee07
- Source dataset