Morpholine → 1,3-Di-cyclopropylmethyl-8-morpholino Xanthine

HRID 3638

Reaction equation

HRID 3638 reaction equation
[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[NH:12][C:11](Cl)=[N:10][C:9]=3[N:8]([CH2:17][CH:18]3[CH2:20][CH2:19]3)[C:6]2=[O:7])[CH2:3][CH2:2]1.[NH:21]1[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>>[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[NH:12][C:11]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:10][C:9]=3[N:8]([CH2:17][CH:18]3[CH2:20][CH2:19]3)[C:6]2=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 98146571,3-Di-cyclopropylmethyl-8-chloroxanthine

Product 1

HCID 99461491,3-Di-cyclopropylmethyl-8-morpholino Xanthine

Procedure

1,3-Di-cyclopropylmethyl-8-morpholino xanthine was prepared from 1,3-di-cyclopropylmethyl-8-chloroxanthine (0.3 g, 0.001 mol) and morpholine (0.2 g, 0.0022 mol) using an analogous procedure to that described in Example 19. The title product was obtained as a crystalline solid, m.pt. >250° C., yield 0.09 g (26%).

Sources & evidence

ORD record
ord-8724cdb4a4f141bd9d5804ebfdc64b3a
Source dataset
uspto-grants-1998_03
Patent number
US05734051

Linked notes

Loading…