Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid

HRID 36413

Reaction equation

HRID 36413 reaction equation
FC1C=C[C:5]([CH:8]2[O:13]C(=O)CC(=O)[O:9]2)=CC=1.[CH:16](=O)[C:17]1[CH:26]=[CH:25][C:22]([O:23][CH3:24])=[C:19]([O:20][CH3:21])[CH:18]=1.C(O)=O>C(N(CC)CC)C>[CH3:21][O:20][C:19]1[CH:18]=[C:17]([CH2:16][CH2:5][C:8]([OH:13])=[O:9])[CH:26]=[CH:25][C:22]=1[O:23][CH3:24]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 8419VeratraldehydeHCID 199386822-(4-Fluorophenyl)-1,3-dioxane-4,6-dione

Product 1

HCID 750193-(3,4-Dimethoxyphenyl)propionic acid

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

5.26 g (0.025 mol) of 2-(4-fluorophenyl)-1,3-dioxane-4,6-dione (m.p.: 166°-167° C.) and 4.15 g (0.025 mol) of veratraldehyde were added to 25 ml of the mixture of formic acid and triethylamine prepared as described in Example 1. The reaction was carried out according to Example 1.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-95f5fe88279f498a8bab78b6b700accd
Source dataset
uspto-grants-1995_05
Patent number
US05414108

Linked notes

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