Formic Acid → 3,4,5-Trimethoxyhydrocinnamic acid

HRID 36415

Reaction equation

HRID 36415 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:13]=[C:14]2C(=O)OC(C)(C)[O:16][C:15]2=[O:23])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].C(O)=O>C(N(CC)CC)C>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([CH2:13][CH2:14][C:15]([OH:23])=[O:16])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 3703232,2-Dimethyl-5-(3,4,5-trimethoxybenzylidene)-1,3-dioxane-4,6-dione

Product 1

HCID 648603,4,5-Trimethoxyhydrocinnamic acid

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

16.1 g (0.05 mol) of 5-(3,4,5-trimethoxyphenylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (m.p.: 159°-160° C.) were added to 50 ml of the mixture of formic acid and triethylamine prepared as described in Example 1, then the procedure described in Example 2 was followed.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-9a4790b671d943c98b12419b5845869e
Source dataset
uspto-grants-1995_05
Patent number
US05414108

Linked notes

Loading…