Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione
Reaction equation
Cl[CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1.[NH3:11]>C(OCC)(=O)C>[NH2:11][CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, and was then separated by filtration and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.
Workup
- customto react overnight in a sealed bomb at about 20° C
- customwas then separated by filtration
- washwashed sequentially with water and methanol
Sources & evidence
- ORD record
- ord-d7456574a0df47a9baefb0d5625c77d9
- Source dataset
- uspto-grants-1986_08
- Patent number
- US04604466
Reaction notes
Loading…