Methylamine → HCID 178485067, compound

HRID 364274

Reaction equation

HRID 364274 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][S:9][CH2:10][CH2:11][NH:12][C:13](=[N:16][C:17]#[N:18])SC)[N:3]=1.[CH3:19][NH2:20]>C(O)C>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][S:9][CH2:10][CH2:11][NH:12][C:13]([NH:20][CH3:19])=[N:16][C:17]#[N:18])[N:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178503928HCID 178503928, compound

Product 1

HCID 178485067HCID 178485067, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-amino-2-[2-(3-cyano-2-methylisothioureido)ethylthiomethyl]pyrimidine (0.75 g.) in 33% w/v methylamine in ethanol (15 ml.) was left at room temperature for 18 hours. The solution was concentrated to 5 ml., cooled in ice, and the crystalline precipitate collected to give 4-amino-2-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]pyrimidine (0.52 g.), m.p. 189°-190°.

Workup

  1. concentrationThe solution was concentrated to 5 ml
  2. temperature, cooled in ice
  3. customthe crystalline precipitate collected

Sources & evidence

ORD record
ord-b4fa69d3d5574b8593f56bc8ccaf3c8b
Source dataset
uspto-grants-1986_08
Patent number
US04604465

Linked notes

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