Methanol → 2-Isopropoxyimino-2-(2-aminothiazol-4-yl)acetic acid
Reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH:15]([CH3:17])[CH3:16])[C:8]([O:10]CC)=[O:9])[N:6]=1.[OH-].[Na+].CO>O1CCCC1>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH:15]([CH3:17])[CH3:16])[C:8]([OH:10])=[O:9])[N:6]=1Participants
5
Procedure
Ethyl 2-(2-aminothiazol-4-yl)-2-iso-propoxyiminoacetate (syn isomer, 26.8 g.), 1N aqueous solution of sodium hydroxide (156 ml.), methanol (156 ml.) and tetrahydrofuran (100 ml.) were treated in a similar manner to that of Example D-(4) to give 2-(2-aminothiazol-4-yl)-2-iso-propoxyiminoacetic acid (syn isomer, 15.3 g.), mp. 151° C. (dec.).
Sources & evidence
- ORD record
- ord-2b4fdb8005c448b19962e1e79045be42
- Source dataset
- uspto-grants-1986_08
- Patent number
- US04604456
Reaction notes
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