Barium → 4-(1H-Imidazol-2-yl)-pyridine
Reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][CH2:9][CH2:10][N:11]=2)=[CH:3][CH:2]=1.[Ba]>C(Cl)Cl>[NH:8]1[CH:9]=[CH:10][N:11]=[C:7]1[C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-(4-pyridyl)-imidazoline (7.0 g, 0.047M) and barium mangnate (52.5 g) in CH2Cl2 (500 ml) were refluxed with stirring for 24 hrs. The reaction mixture was then filtered through diatomaceous earth, washed with methylene chloride and then ethylacetate. The combined filtrates were concentrated and crystallized from ethylacetate-petroleum ether to give 4-(1H-imidazol-2-yl)pyridine (4.7 g, 67% yield).
Workup
- filtrationThe reaction mixture was then filtered through diatomaceous earth
- washwashed with methylene chloride
- concentrationThe combined filtrates were concentrated
- customcrystallized from ethylacetate-petroleum ether
Sources & evidence
- ORD record
- ord-8d2006b4e8cb47d7b5b819625280b916
- Source dataset
- uspto-grants-1986_08
- Patent number
- US04605744
Reaction notes
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