Phenol → 2-Isopropylphenol

HRID 36478

Reaction equation

HRID 36478 reaction equation
C1(O)C=CC=CC=1.[CH:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13](C(C)C)[C:12]=1[OH:20])([CH3:10])[CH3:9]>[O-]C1C=CC=CC=1.[Al+3].[O-]C1C=CC=CC=1.[O-]C1C=CC=CC=1>[CH:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[OH:20])([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 996PhenolHCID 4943Propofol

Product 1

HCID 69432-IsopropylphenolYield 11.3%

Reagents, catalysts & solvents 1

HCID 167236Phenol, aluminum salt (3:1)Catalyst

Procedure

For example, U.S. Pat. No. 2,831,898 discloses a process for producing 2,6-diisopropyl phenol from propylene gas and phenol by Friedel-Crafts reaction at high pressure of 21-35 atm, high temperature of 200°-210° C. and under nitrogen atmosphere with aluminum phenoxide, as a catalyst, prepared from alumina and phenol. But there is a defect that 2,6-diisopropyl phenol desired was obtained only with 11.3% yield even though 2-isopropyl phenol which is a by-product was obtained with 31.4% yield.

Workup

  1. customby Friedel-Crafts reaction at high pressure of 21-35 atm, high temperature of 200°-210° C.

Sources & evidence

ORD record
ord-ecc444f57693423e9e56e8881183e4e1
Source dataset
uspto-grants-1995_05
Patent number
US05414156

Linked notes

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