Hydroxyamine hydrochloride → Benzyl 3-pyridyl ketone oxime

HRID 365109

Reaction equation

HRID 365109 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=O)[CH:2]=1.Cl.[NH2:17][OH:18]>N1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=[N:17][OH:18])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 43289002-Phenyl-1-pyridin-3-yl-ethanone

Product 1

HCID 72739677Benzyl 3-pyridyl ketone oxime

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

10.8 g of benzyl 3-pyridyl ketone are stirred together with 40 ml of pyridine and a solution of 8 g of hydroxylamine hydrochloride in 15 ml of pyridine for 6 hours at 100°. The reaction mixture is poured onto ice/water and the resulting mixture is stirred for a further 15 minutes. The crystals which have precipitated are filtered off with suction, washed with water and dried under a high vacuum. Benzyl 3-pyridyl ketone oxime with a melting point of 122°-126° is obtained.

Workup

  1. additionThe reaction mixture is poured onto ice/water
  2. customThe crystals which have precipitated
  3. filtrationare filtered off with suction
  4. washwashed with water
  5. customdried under a high vacuum

Sources & evidence

ORD record
ord-a90870b128de4b52a48d18d809241cea
Source dataset
uspto-grants-1986_08
Patent number
US04608382

Linked notes

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