1,2-Dimethylhydrazine → 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone
Reaction equation
[CH3:1][CH:2]([C:8]([O:10]CC)=O)[C:3](OCC)=[O:4].[CH3:13][NH:14][NH:15][CH3:16].C[O-].[Na+]>CO>[OH:10][C:8]1[N:14]([CH3:13])[N:15]([CH3:16])[C:3](=[O:4])[C:2]=1[CH3:1]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Diethyl methylmalonate and N,N'-dimethylhydrazine are heated under reflux for 170 hours in methanol in the presence of sodium methylate under an atmosphere of nitrogen. 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone is obtained in the form of colorless crystals which, after recrystallization from ethyl acetate, melt at 87°-89° C.
Sources & evidence
- ORD record
- ord-da58efdd8cfd44639ad1ce4e0173a134
- Source dataset
- uspto-grants-1986_08
- Patent number
- US04608383
Reaction notes
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