Citric Acid → DL-Malate

HRID 36555

Reaction equation

HRID 36555 reaction equation
[C:1]([OH:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].[C:14]([OH:22])(=[O:21])[CH:15]([CH2:17][C:18]([OH:20])=[O:19])[OH:16].C(=O)(O)[O-].[Na+:27]>>[C:1]([O-:13])(=[O:12])[CH2:2][C:3]([CH2:8][C:9]([OH:11])=[O:10])([C:5]([OH:7])=[O:6])[OH:4].[Na+:27].[C:14]([O-:22])(=[O:21])[CH:15]([CH2:17][C:18]([O-:20])=[O:19])[OH:16]

Participants

5

Reactant 3

HCID 311Citric AcidHCID 525Malic AcidHCID 516892Sodium Bicarbonate

Product 2

HCID 160434DL-MalateHCID 23666341Monosodium Citrate

Procedure

Process: Heat citric acid to 60° C. and moisten with 8 ml of 60% malic acid solution. Allow sodium bicarbonate I to react to give monosodium citrate and malate; then allow sodium bicarbonate II and potassium bicarbonate to undergo partial reaction. Add sodium carbonate and allow partial reaction, and then dry in vacuo. Mix the resulting granules with arginine aspartate and the additives (Sweetener, aroma) and compress to give tablets.

Workup

  1. customto react

Sources & evidence

ORD record
ord-7ace711f97f347e18fe09e01b3b7b582
Source dataset
uspto-grants-1995_05
Patent number
US05415870

Linked notes

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