Bromoacetyl chloride → 4-Bromoacetyl-2,3,4,5-tetrahydro-1,4-benzothiazepine

HRID 36564

Reaction equation

HRID 36564 reaction equation
[S:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][NH:4][CH2:3][CH2:2]1.[Br:12][CH2:13][C:14](Cl)=[O:15]>C(N(CC)CC)C>[Br:12][CH2:13][C:14]([N:4]1[CH2:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[S:1][CH2:2][CH2:3]1)=[O:15]

Participants

4

Reactant 2

HCID 89602Bromoacetyl chlorideHCID 122691062,3,4,5-Tetrahydrobenzo[f][1,4]thiazepine

Product 1

HCID 152916574-Bromoacetyl-2,3,4,5-tetrahydro-1,4-benzothiazepineYield 42.1%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2,3,4,5-Tetrahydro-1,4-benzothiazepine (4.8 g), triethylamine (5.9 g) and bromoacetyl chloride (5.5 g) were reacted in the same manner as in Experimental Example 1 to give 4-bromoacetyl-2,3,4,5-tetrahydro-1,4-benzothiazepine (3.5 g).

Sources & evidence

ORD record
ord-b064d53212ac4e57835ad8c2d0a85198
Source dataset
uspto-grants-1995_05
Patent number
US05416066

Linked notes

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