HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, N-propyl- → 2-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, N-propyl- | HCID 12153 | — |
| Reactant | Ammonium thiocyanate | HCID 15666 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one | HCID 23287716 | 80.5% |
Reaction Steps
The reaction procedure of Example 57 was followed except that 1.763 g (11.2 mmol) of 2-chloronicotinic acid, 15 ml of thionyl chloride, two droplets of DMF, 894 mg of ammonium thiocyanate, 15 ml of acetone, 1.59 g of N-propylaniline and 10 ml of acetone were used. The product was then recrystallized from ethanol to obtain 2.68 g of 2-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133258 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-c2e12f5aa62d4bf8bada23e707904610 |
| Source note | uspto-grants-2000_10 |