Benzenamine, N-propyl- → 2-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one

HRID 367157ノート

反応式

HRID 367157 の反応式
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.S(Cl)(Cl)=O.[S-:15][C:16]#[N:17].[NH4+].[CH2:19]([NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:20][CH3:21]>CC(C)=O.CN(C=O)C>[C:23]1([N:22]([C:16]2[S:15][C:2]3[N:10]=[CH:9][CH:8]=[CH:7][C:3]=3[C:4](=[O:6])[N:17]=2)[CH2:19][CH2:20][CH3:21])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

参加物

7

反応物 4

HCID 12153Benzenamine, N-propyl-HCID 15666Ammonium thiocyanateHCID 24386Thionyl ChlorideHCID 762582-Chloronicotinic acid

生成物 1

HCID 232877162-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one収率 80.5%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒2 回HCID 6228Dimethylformamide溶媒

実験手順

The reaction procedure of Example 57 was followed except that 1.763 g (11.2 mmol) of 2-chloronicotinic acid, 15 ml of thionyl chloride, two droplets of DMF, 894 mg of ammonium thiocyanate, 15 ml of acetone, 1.59 g of N-propylaniline and 10 ml of acetone were used. The product was then recrystallized from ethanol to obtain 2.68 g of 2-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

後処理

  1. customThe reaction procedure of Example 57
  2. customThe product was then recrystallized from ethanol

出典と根拠

ORDレコード
ord-c2e12f5aa62d4bf8bada23e707904610
出典データセット
uspto-grants-2000_10
特許番号
US06133258

反応ノート

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