Ammonium thiocyanate → HCID 23287621, compound

HRID 367209

Reaction equation

HRID 367209 reaction equation
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S-:11][C:12]#[N:13].[NH4+].[CH3:15][NH:16][C:17]1[CH:21]=[CH:20][S:19][CH:18]=1>CC(C)=O>[CH3:15][N:16]([C:12]1[S:11][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4](=[O:5])[N:13]=1)[C:17]1[CH:21]=[CH:20][S:19][CH:18]=1

Participants

5

Reactant 3

HCID 15666Ammonium thiocyanateHCID 642344N-methylthiophen-3-amineHCID 27745412-Chloronicotinoyl chloride

Product 1

HCID 23287621HCID 23287621, compoundYield 26.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The reaction procedure of Example 102 was followed except that 560 mg of 2-chloronicotinoyl chloride, 242 mg of ammonium thiocyanate, 360 mg of 3-(methylamino)thiophene and 10 ml of acetone were used. The product was then recrystallized from a mixture of ethanol and chloroform to obtain 230 mg of 2-[N-methyl-N-(3-thienyl)amino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

Workup

  1. customThe reaction procedure of Example 102
  2. customThe product was then recrystallized from a mixture of ethanol and chloroform

Sources & evidence

ORD record
ord-f44349c4c9634de7b3e5f2bc8b5ad0da
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Linked notes

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