Hydrogen Peroxide → 2,3-Difluorophenol

HRID 36816

Reaction equation

HRID 36816 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1B(O)O.[OH:12]O>CCOCC>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:12]

Participants

4

Reactant 2

HCID 784Hydrogen Peroxide2×HCID 2734333(2,3-Difluorophenyl)boronic acid

Product 1

HCID 808792,3-Difluorophenol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The boronic acid in an amount of 9.0 g was dissolved in 60 ml of an ether, and the solution thus formed was added dropwise with 60 ml of a 10% aqueous hydrogen peroxide while being refluxed under a heated condition. After the dropping of the aqueous hydrogen peroxide was finished, the reflux under a heated condition was further continued for 2 hours. Then, the ether layer was separated with a separating funnel, washed with water, dried, and then subjected to distillation under a reduced pressure to separate the solvent to obtain 7.1 g of 2,3-difluorophenol.

Workup

  1. customthe solution thus formed
  2. temperaturewhile being refluxed under a heated condition
  3. temperaturethe reflux under a heated condition
  4. customThen, the ether layer was separated with a separating funnel
  5. washwashed with water
  6. customdried
  7. distillationsubjected to distillation under a reduced pressure
  8. customto separate the solvent

Sources & evidence

ORD record
ord-5126645cd7c5425d9a55f5c7ca5fdb54
Source dataset
uspto-grants-1995_05
Patent number
US05417885

Linked notes

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