Hydroxyamine hydrochloride → HCID 178513387, compound
Reaction equation
[ClH:1].[NH2:2][OH:3].C[O-].[Na+].Cl[C:8]1[CH:9]=[C:10]([C:15]#[N:16])[CH:11]=[N:12][C:13]=1[Cl:14]>CO>[Cl:1][C:8]1[CH:9]=[C:10]([C:15](=[NH:16])[NH:2][OH:3])[CH:11]=[N:12][C:13]=1[Cl:14]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Hydroxylamine hydrochloride (2.6 g, 0.038 mol) was slurried in methanol (75 mL) and sodium methoxide (2.0 g, 0.037 mol) added. The mixture was stirred for half an hour and 5,6-dichloro-3-pyridinecarbonitrile (4.3 g, 0.025 mol) added. The mixture was stirred at room temperature overnight and filtered. The precipitate was washed with water and methanol and dried to give the desired product (4.2 g, 82%) as a white solid, MP 182-184° C.
Workup
- stirringThe mixture was stirred at room temperature overnight
- filtrationfiltered
- washThe precipitate was washed with water and methanol
- customdried
Sources & evidence
- ORD record
- ord-ec543ccb5e3a4768bbdce4c8798977de
- Source dataset
- uspto-grants-2000_10
- Patent number
- US06133294
Reaction notes
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