1,1-Dimethoxyethyl(dimethyl)amine → N-[1-(Dimethylamino)ethylidene]-5,6-dichloro-3-pyridinecarboxamide
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([NH2:11])=[O:10])[CH:5]=[N:6][C:7]=1[Cl:8].CO[C:14](OC)([N:16]([CH3:18])[CH3:17])[CH3:15]>>[CH3:17][N:16]([CH3:18])[C:14](=[N:11][C:9]([C:4]1[CH:5]=[N:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)=[O:10])[CH3:15]Participants
3
Conditions
- Temperature
- 120 °C
Procedure
A mixture of 5,6-dichloro-3-pyridinecarboxamide (4.0 g, 0.02 mol), dimethylacetamide dimethyl acetal (8 mL) was heated in an oil bath at 120° C. for three hours. The reaction mixture was cooled to room temperature and the solid recrystallised from ethyl acetate:hexane in the presence of activated carbon to give the desired product (2.3 g, 42%) as an orange solid.