Hydrogen Bromide → HCID 23284711, compound
Reaction equation
[Cl:1][C:2]1[C:3]([F:31])=[C:4]([F:30])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[C:16]([O:18]C)[C:15]([F:20])=[CH:14][C:13]=1[N+:21]([O-:23])=[O:22])[CH:9]=[C:8]([C:24]([O:26]CC)=[O:25])[C:7]2=[O:29].Br>C(O)(=O)C>[Cl:1][C:2]1[C:3]([F:31])=[C:4]([F:30])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[C:16]([OH:18])[C:15]([F:20])=[CH:14][C:13]=1[N+:21]([O-:23])=[O:22])[CH:9]=[C:8]([C:24]([OH:26])=[O:25])[C:7]2=[O:29]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethyl 8-chloro-6,7-difluoro-1-(4-fluoro-5-methoxy-2-nitrophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (510 mg) was added to a mixed liquid (1:1, v/v; 5 ml) of 47% hydrobromic acid and acetic acid, aid the mixture was stirred and heated under reflux for 46 hours. The reaction mixture was concentrated under reduced pressure. A process of adding distilled water (5 ml) to the residue and then concentrating the mixture under reduced pressure was conducted twice repeatedly. Distilled water (5 ml) was added to the resultant residue, and deposits were collected by filtration. The deposits were dispersed in ethanol (2 ml) and heated to reflux. The reaction mixture was allowed to cool, and deposits were collected by filtration and washed with ethanol and diisopropyl ether in that order to obtain the title compound (220 mg) as a pale brown powder.