Dimethylformamide dimethyl acetal → Ethyl 2-cyano-5-dimethylamino-3-methylpenta-2,4-dienoate
Reaction equation
[C:1](=[C:4]([C:10]#[N:11])[C:5]([O:7][CH2:8][CH3:9])=[O:6])([CH3:3])[CH3:2].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>C(O)C>[C:10]([C:4](=[C:1]([CH3:2])[CH:3]=[CH:14][N:15]([CH3:17])[CH3:16])[C:5]([O:7][CH2:8][CH3:9])=[O:6])#[N:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 127.7 g (0.839 mole) of ethyl isopropylidenecyanoacetate (4) and 100 g (0.839 mole) of N.N-dimethylformamide dimethyl acetal in 500 mL of ethanol was refluxed for 24 hours. The ethanol was removed under reduced pressure to give 124 g (100%) of a dark oil.
Workup
- temperaturewas refluxed for 24 hours
- customThe ethanol was removed under reduced pressure
Sources & evidence
- ORD record
- ord-0e34adf709a642c9b585539b628c6eb3
- Source dataset
- uspto-grants-2000_10
- Patent number
- US06136982
Reaction notes
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