1,2,3,4-Tetrahydroquinoline → 4-(1,2,3,4-Tetrahydroquinolin-1-yl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine

HRID 369706

Reaction equation

HRID 369706 reaction equation
Cl[C:2]1[C:3]2[C:10]([CH3:11])=[C:9]([CH3:12])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][CH2:14]1>C1(C)C=CC=CC=1.CC(C)=O>[N:13]1([C:2]2[C:3]3[C:10]([CH3:11])=[C:9]([CH3:12])[NH:8][C:4]=3[N:5]=[CH:6][N:7]=2)[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 694601,2,3,4-TetrahydroquinolineHCID 130411444-chloro-5,6-dimethyl-7H-pyrrolo(2,3-d)pyrimidine

Product 1

HCID 232824624-(1,2,3,4-Tetrahydroquinolin-1-yl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 20247278Toluene acetoneSolvent

Procedure

This product is prepared in a manner analogous to that described in Example 1 from 4-chloro-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine and 1,2,3,4-tetrahydroquinoline (4 equivalents, Fluka, Buchs, Switzerland). M.p: 263-264° C.; FAB-MS: (M+H)+ =279 (corresponds to C17H18N4); Rf value (toluene-acetone--(4:6))=0.29.

Workup

  1. customThis product is prepared in a manner analogous to

Sources & evidence

ORD record
ord-76ac5485e1334e7499be9b28474d231e
Source dataset
uspto-grants-2000_10
Patent number
US06140317

Linked notes

Loading…