Methanol → 2-Methoxy-4-(cyclopropylamino)-6-(1-methylethylamino)-1,3,5-triazine

HRID 370609

Reaction equation

HRID 370609 reaction equation
[Na].Cl[C:3]1[N:8]=[C:7]([NH:9][CH:10]2[CH2:12][CH2:11]2)[N:6]=[C:5]([NH:13][CH:14]([CH3:16])[CH3:15])[N:4]=1.[CH3:17][OH:18]>>[CH3:17][O:18][C:3]1[N:8]=[C:7]([NH:9][CH:10]2[CH2:12][CH2:11]2)[N:6]=[C:5]([NH:13][CH:14]([CH3:16])[CH3:15])[N:4]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 24738CyprazineHCID 5360545Sodium

Product 1

HCID 202748622-Methoxy-4-(cyclopropylamino)-6-(1-methylethylamino)-1,3,5-triazine

Procedure

2.1 g of sodium was added in portions to 400 ml of stirred anhydrous methanol. The solution was allowed to cool to room temperature, then 16.5 g of 9B was added and the mixture was refluxed for 2 hours. The solvent was evaporated, and the residue was washed with water, then extracted with ether. The extract phase was dried (MgSO4) and stripped of solvent to give 2-methoxy-4-(cyclopropylamino)-6-(1-methylethylamino)-1,3,5-triazine (13A).

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent was evaporated
  3. washthe residue was washed with water
  4. extractionextracted with ether
  5. dry with materialThe extract phase was dried (MgSO4)

Sources & evidence

ORD record
ord-a3dd8f3efd3d43f2ba7a1f82d6b37e86
Source dataset
uspto-grants-1985_07
Patent number
US04528027

Linked notes

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