Ethyl Bromide → 5-Ethylthiopyrano[3,2-b]indol-4(5H)-one

Reaction equation

[S:1]1[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[NH:6][C:5]=2[C:4](=[O:14])[CH:3]=[CH:2]1.[CH2:15](Br)[CH3:16]>>[CH2:15]([N:6]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[C:13]2[S:1][CH:2]=[CH:3][C:4](=[O:14])[C:5]1=2)[CH3:16]

Participants

Reactant 2

HCID 6332Ethyl Bromide

HCID 20326608Thiopyrano[3,2-b]indol-4(5H)-one

Product 1

HCID 203266205-Ethylthiopyrano[3,2-b]indol-4(5H)-one

Procedure

-- By the same method as described in Example 7, 4.8 g of thiopyrano [3,2-b]-indol-4(5H)-one is alkylated with ethyl bromide to give 4.8 g of product, mp 103°-104° C, after recrystallization from methylene chloride-hexane.

Sources & evidence

ORD record: ord-f5763fe3daf54532ab30dda8579887ea
Source dataset: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04092328

Reaction notes

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