Hydrochloric Acid → Glycyl-glycine benzyl ester hydrochloride

HRID 372771

Reaction equation

HRID 372771 reaction equation
[CH2:1]([O:8][C:9](=[O:23])[CH2:10][NH:11][C:12](=[O:22])[CH2:13][NH:14]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:24]>O1CCOCC1>[ClH:24].[CH2:1]([O:8][C:9](=[O:23])[CH2:10][NH:11][C:12](=[O:22])[CH2:13][NH2:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3244524Benzyl (tert-butoxycarbonyl)glycylglycinate

Product 1

HCID 13996146Glycyl-glycine benzyl ester hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

10.3 Parts N-t-butoxycarbonylglycylglycine benzyl ester is dissolved in 200 parts dioxane and treated with a 10 fold excess of 2 N hydrochloric acid in dioxane for 10 minutes. Removal of the solvent under reduced pressure affords pure glycylglycine benzyl ester hydrochloride.

Workup

  1. customRemoval of the solvent under reduced pressure

Sources & evidence

ORD record
ord-649622d36011435d853bf41132b09046
Source dataset
uspto-grants-1978_05
Patent number
US04092304

Linked notes

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