Hydrochloric Acid → Ethyl phosphonoacetate
Reaction equation
[P:1]([CH2:5][C:6]([OH:8])=[O:7])([OH:4])([OH:3])=[O:2].Cl.[CH2:10](O)[CH3:11]>>[P:1]([CH2:5][C:6]([O:8][CH2:10][CH3:11])=[O:7])([OH:4])([OH:3])=[O:2]Participants
4
Procedure
Into 100 ml. of absolute ethanol was placed 28 g. (0.2 mole) of phosphonoacetic acid. The solution was treated with a stream of dry hydrogen chloride at 0° C. for 45 minutes. After refluxing for 3 hours the solution was allowed to stand overnight at room temperature. Evaporation of the solvent yielded a viscous oil, which was dried in vacuo over P2O5 and NaOH.
Workup
- temperatureAfter refluxing for 3 hours the solution
- customEvaporation of the solvent
- customyielded a viscous oil, which
- dry with materialwas dried in vacuo over P2O5 and NaOH
Sources & evidence
- ORD record
- ord-5ffe54c0372844fe9942268a808f2423
- Source dataset
- uspto-grants-1978_05
- Patent number
- US04092412
Reaction notes
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