Sodium Hydroxide → 4-Pentyl-1H-pyrazole

Temperature

90 °C

4-Pentylpyrazole (4-PeP) was prepared by adding 2-Pentyl-1,1,3,3-tetraethoxypropane dropwise with stirring to a solution having a molar equivalent of hydrazine sulfate in 6M HCl at 40°-45° C. The mixture was kept at this temperature for 1 hour and the temperature then raised to 90° C. for 30 minutes. After the mixture cooled, 40% w/w 30 NaOH was added and the mixture thoroughly extracted with ether. Drying the ether solution over MgSO4 afforded 4-PeP. Stock solutions of 4-PeP (3 mM) were prepared by dissolution first in acetonitrile, followed by dilution with water to a final acetonitrile concentration of 8%.

1. custom4-Pentylpyrazole (4-PeP) was prepared
2. customat 40°-45° C
3. temperatureAfter the mixture cooled
4. extractionthe mixture thoroughly extracted with ether
5. dry with materialDrying the ether solution over MgSO4

ORD record

ord-577ba6c4cd0f4e29a4a01f3d29372537

Source dataset

uspto-grants-1992_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05162203