Hydrochloric Acid → Morpholin-2-ylmethanol hydrochloride

Reaction equation

C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][OH:15])[CH2:9]1)C1C=CC=CC=1.C(N1CCOC(COC)C1)C1C=CC=CC=1.C(O)C.[ClH:35]>>[ClH:35].[OH:15][CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 2776358(4-Benzylmorpholin-2-yl)methanol

HCID 103534614-Benzyl-2-(methoxymethyl)morpholine

Product 1

HCID 19777263Morpholin-2-ylmethanol hydrochloride

Procedure

N-Benzyl-2-hydroxymethylmorpholine prepared in the same manner as described in Synthetic Communication, Vol. 10 (1), pages 59-73, 1980 (1.3 g) is subjected to hydrogenolysis in hydrogen chloride-containing ethanol in the same manner as described in Reference Example 15 to give 2-hydroxymethylmorpholine hydrochloride (1.3 g).