2-Ethylimidazole → 1-Ethylimidazo[1,5-a]pyrido[4,5-e]pyrazine-4(5H)-one

HRID 374096

Reaction equation

HRID 374096 reaction equation
F[C:2]1[CH:3]=[N+:4]([O-])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O.[CH2:12]([C:14]1[NH:15][CH:16]=[CH:17][N:18]=1)[CH3:13].[C:19](N1C=CN=C1)(N1C=CN=C1)=[O:20]>[Pd]>[CH2:12]([C:14]1[N:18]2[C:2]3[CH:3]=[N:4][CH:5]=[CH:6][C:7]=3[NH:8][C:19](=[O:20])[C:17]2=[CH:16][N:15]=1)[CH3:13]

Participants

5

Reactant 3

HCID 661302-EthylimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 5940283-Fluoro-4-nitropyridin-1-ium-1-olate

Product 1

HCID 198093911-Ethylimidazo[1,5-a]pyrido[4,5-e]pyrazine-4(5H)-one

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepare by reaction of 3-fluoro-4-nitropyridine-N-oxide with 2-ethylimidazole followed by hydrogenation with Pd-C and cyclization with carbonyldiimidazole to provide the title compound.

Sources & evidence

ORD record
ord-592e86204a82466c93402b1bb0123d83
Source dataset
uspto-grants-1992_11
Patent number
US05166344

Linked notes

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