4-Hydroxybutanal → 1,4-Butanediol

HRID 374200

Reaction equation

HRID 374200 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH:5]=[O:6].[OH:7][CH2:8][CH:9]([CH3:12])[CH:10]=[O:11]>O1CCCC1>[CH2:5]([OH:6])[CH2:4][CH2:3][CH2:2][OH:1].[CH3:12][CH:9]([CH2:10][OH:11])[CH2:8][OH:7]

Participants

5

Reactant 2

HCID 930934-HydroxybutanalHCID 110297623-Hydroxy-2-methylpropanal

Product 2

HCID 80641,4-ButanediolHCID 75103Methylpropanediol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

The invention relates to the preparation of tetrahydrofuran. In particular, a mixture of 4-hydroxybutanal and 3-hydroxy-2-methylpropanal is hydrogenated in the presence of a supported transition metal catalyst to give tetrahydrofuran as the major product, and 1,4-butanediol and 2-methyl-1,3-propanediol as minor products.

Sources & evidence

ORD record
ord-1f83adcc5a764fc89dcdd93799091101
Source dataset
uspto-grants-1992_11
Patent number
US05166370

Linked notes

Loading…