HCID 20788751, compound → HCID 20788749, compound
Reaction equation
C([O:5][C:6](=[O:27])[C@H:7]([CH3:26])[NH:8][C:9](=[O:25])[CH:10]([O:14][C:15]1[N:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH3:24])[N:16]=1)[CH:11]([CH3:13])[CH3:12])(C)(C)C>FC(F)(F)C(O)=O>[CH3:22][O:21][C:19]1[CH:18]=[C:17]([O:23][CH3:24])[N:16]=[C:15]([O:14][CH:10]([CH:11]([CH3:13])[CH3:12])[C:9]([NH:8][C@H:7]([C:6]([OH:27])=[O:5])[CH3:26])=[O:25])[N:20]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
2 g of N-[2-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-methyl-butyryl]-L-alanine tert-butyl ester (Example 1.023) are added to 20 ml of trifluoroacetic acid. After one hour, the reaction mixture is concentrated by evaporation, taken up in ethyl acetate, washed once with dilute hydrochloric acid, dried over sodium sulfate and again concentrated by evaporation, yielding N-[2-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-methyl-butyryl]-L-alanine as a crystalline product; m.p.: 157°-160° C. (from ethyl acetate).
Workup
- concentrationthe reaction mixture is concentrated by evaporation