Dimethyl Sulfoxide → 2-(1-(Benzyloxyamino)ethyl)benzo[b]thiophene

HRID 37515

Reaction equation

HRID 37515 reaction equation
Cl[CH:2]([C:4]1[S:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[CH:5]=1)[CH3:3].[CH2:13]([O:20][NH2:21])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CS(C)=O>O1CCCC1>[CH2:13]([O:20][NH:21][CH:2]([C:4]1[S:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[CH:5]=1)[CH3:3])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 102313O-BenzylhydroxylamineHCID 187792542-(1-Chloroethyl)benzo[b]thiophene

Product 1

HCID 199358882-(1-(Benzyloxyamino)ethyl)benzo[b]thiophene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

heating 2-(1-chloroethyl)benzo[b]thiophene with O-benzylhydroxylamine in a solvent such as dimethyl sulphoxide or tetrahydrofuran to give 2-(1-(benzyloxyamino)ethyl)benzo[b]thiophene of formula: ##STR4##

Sources & evidence

ORD record
ord-00f36ee121f6420c94f2834e54e0d4f7
Source dataset
uspto-grants-1995_05
Patent number
US05420300

Linked notes

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