N,N,N',N'-Tetramethylethylenediamine → HCID 178506664, compound

HRID 37592

Reaction equation

HRID 37592 reaction equation
CN(C)CCN(C)C.[CH2:9]([Li:13])[CH2:10][CH2:11][CH3:12].[F:14][C:15]1([F:24])[O:19][C:18]2C=CC=C[C:17]=2[O:16]1>C1(C)C=CC=CC=1.CCCC>[F:14][C:15]1([F:24])[O:19][C:18]2[CH:12]=[CH:11][CH:10]=[C:9]([Li:13])[C:17]=2[O:16]1

Participants

6

Reactant 3

HCID 8037N,N,N',N'-TetramethylethylenediamineHCID 741032,2-Difluoro-1,3-benzodioxoleHCID 178418339Butyllithium

Product 1

HCID 178506664HCID 178506664, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 7843ButaneSolvent

Procedure

39.3 g (339 mmol) of N,N,N',N'-tetramethylethylenediamine are added dropwise under a nitrogen atmosphere at from -15° to -10° C. to 137.8 g (409 mmol) of n-butyllithium solution (19.0% in toluene). The resulting reaction mixture is added dropwise at from -15° to -10° C. under a nitrogen atmosphere to a solution of 53.3 g (337 mmol) of 2,2-difluoro-1,3-benzodioxole in 46 ml of toluene, n-butane being formed in addition to the title compound.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-3582885ae8144c71a31f109c4e589b25
Source dataset
uspto-grants-1995_05
Patent number
US05420301

Linked notes

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