Sodium Hydroxide → 2-(Propylthio)pyrimidine-4,6-diol

HRID 378841

Reaction equation

HRID 378841 reaction equation
[CH2:1](I)[CH2:2][CH3:3].[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([SH:13])[N:7]=1.[OH-].[Na+]>O>[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([S:13][CH2:1][CH2:2][CH3:3])[N:7]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 336431-IodopropaneHCID 178516656HCID 178516656, compound

Product 1

HCID 1784608102-(Propylthio)pyrimidine-4,6-diol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Propyl iodide (136 ml) was added to a suspension of 4,6-dihydroxy-2-mercaptopyrimidine (200 g) in water (800 ml), containing sodium hydroxide (55.6 g). The reaction mixture was stirred for 2 weeks then concentrated to half volume, 2N hydrochloric acid was added and the subtitle compound was isolated by filtration (167 g).

Workup

  1. concentrationthen concentrated to half volume, 2N hydrochloric acid
  2. additionwas added

Sources & evidence

ORD record
ord-6e83b0f2d6c14146a36cb58912dd272d
Source dataset
uspto-grants-2001_10
Patent number
US06297232B1

Linked notes

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