Hydrochloric Acid → HCID 178433207, compound
Reaction equation
[NH:1]([C:5]1[S:6][C:7]([C:11]([NH:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][C:19]([O:21]CCCC)=[O:20])=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3].[ClH:26]>>[ClH:26].[NH:1]([C:5]1[S:6][C:7]([C:11]([NH:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][C:19]([OH:21])=[O:20])=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3]Participants
3
Procedure
151 mg of butyl {3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-propoxy}-acetate are stirred for 5 hrs. in 3 ml of 25% hydrochloric acid. The reaction mixture is evaporated to dryness in a vacuum and the residue is lyophilized from acetic acid. There are obtained 144 mg of [3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-propoxy]-acetic acid hydrochloride (1:1), m.p. 48-51° C., MS: 316 (M+H)+.
Workup
- customThe reaction mixture is evaporated to dryness in a vacuum
Sources & evidence
- ORD record
- ord-cea242e95d754bfdb8fa270b97808cb8