2-Methylbenzyl alcohol → 2-Methylbenzaldehyde

HRID 379362

Reaction equation

HRID 379362 reaction equation
CC1C=CC=CC=1C.N[C:10]1[CH:21]=[CH:20][CH:19]=[C:12]2[C:13](N(O)[C:16](=O)[C:11]=12)=[O:14].CC1C=CC=CC=1CO>>[CH3:16][C:11]1[CH:10]=[CH:21][CH:20]=[CH:19][C:12]=1[CH:13]=[O:14]

Participants

4

Reactant 3

HCID 69942-Methylbenzyl alcoholHCID 7237O-XyleneHCID 108884723-amino-N-hydroxyphthalimide2×

Product 1

HCID 107222-MethylbenzaldehydeYield 30%

Procedure

170 mg (1.60 mmol) of o-xylene were reacted analogously to Example 1 in the presence of 32.1 mg (0.180 mmol) of 3-amino-N-hydroxyphthalimide. After a reaction time of 4 hours and 18 hours, a further 32.1 mg (0.180 mmol) of 3-amino-N-hydroxyphthalimide were added in each case, and, after a total of 30 hours, the reaction solution was extracted with chloroform and examined by NMR spectroscopy. Yield 30% of 2-methylbenzaldehyde and 7% of 2-methylbenzyl alcohol.

Workup

  1. extractionafter a total of 30 hours, the reaction solution was extracted with chloroform

Sources & evidence

ORD record
ord-1891e06b840d49d48dfd203a556d703d
Source dataset
uspto-grants-2001_10
Patent number
US06297403B1

Linked notes

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