Triethylamine → HCID 178418549, compound

HRID 3794

Reaction equation

HRID 3794 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[ClH:5].Cl.[Cl:7][C:8]1[CH:24]=[CH:23][C:11]([CH2:12][N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][SH:22])[CH2:15][CH2:14]2)=[CH:10][CH:9]=1.C(N(CC)CC)C>C(Cl)Cl>[ClH:7].[ClH:5].[CH3:1][NH:2][C:3](=[SH:22][CH2:21][CH2:20][CH2:19][N:16]1[CH2:17][CH2:18][N:13]([CH2:12][C:11]2[CH:10]=[CH:9][C:8]([Cl:7])=[CH:24][CH:23]=2)[CH2:14][CH2:15]1)[OH:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 137311183-[4-(4-Chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride

Product 1

HCID 178418549HCID 178418549, compoundYield 64.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The procedure described in Example 2 was followed, using 0.4 g of methyl isocyanate, 2.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride, 0.7 g of triethylamine and 50 ml of methylene chloride, to give 0.75 g (32% of theory) of N-methyl-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 240°-243° C.

Sources & evidence

ORD record
ord-3d2e024e70544f24ae5de4bfff5d6753
Source dataset
uspto-grants-1988_02
Patent number
US04722926

Linked notes

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