Potassium Carbonate → Tert-butyl 2-(4-chloro-2-formylphenoxy)acetate

HRID 38257

Reaction equation

HRID 38257 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[C:6]([CH:7]=[O:8])[CH:9]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 124815-Chloro-salicylaldehydeHCID 79177tert-Butyl bromoacetate

Product 1

HCID 51357407Tert-butyl 2-(4-chloro-2-formylphenoxy)acetate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The sub-title compound was prepared by the method of Example 1 part d) using 5-chloro-2-hydroxybenzaldehyde (40 g), potassium carbonate (40 g), acetone (400 ml) and tert-butyl bromoacetate (37 ml) (yield=45.5 g).

Sources & evidence

ORD record
ord-1c466732972d4d2c88e1ad16807ce345
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Linked notes

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