Phenylmethanesulfonyl chloride → [4-Chloro-2-[4-[(phenylmethyl)sulfonyl]-1-piperazinyl]phenoxy]-acetic acid

HRID 38264

Reaction equation

HRID 38264 reaction equation
Cl.[Cl:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH2:8][C:9]([O:11]CC)=[O:10])=[C:5]([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH:4]=1.[CH:22]1[CH:27]=[CH:26][C:25]([CH2:28][S:29](Cl)(=[O:31])=[O:30])=[CH:24][CH:23]=1>>[Cl:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH2:8][C:9]([OH:11])=[O:10])=[C:5]([N:16]2[CH2:17][CH2:18][N:19]([S:29]([CH2:28][C:25]3[CH:26]=[CH:27][CH:22]=[CH:23][CH:24]=3)(=[O:31])=[O:30])[CH2:20][CH2:21]2)[CH:4]=1

Participants

3

Reactant 2

HCID 74740Phenylmethanesulfonyl chlorideHCID 86631058[4-chloro-2-(1-piperazinyl)phenoxy]-acetic Acid, Ethyl Ester Hydrochloride Salt

Product 1

HCID 11568054[4-Chloro-2-[4-[(phenylmethyl)sulfonyl]-1-piperazinyl]phenoxy]-acetic acid

Procedure

Prepared from the product from Example 38 step c) and benzenemethanesulfonyl chloride according to the procedure described in Example 38 step d) to give the sub-title compound as a white solid.

Sources & evidence

ORD record
ord-92c4883201fb4ee6b1ddd377316c0e3f
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Linked notes

Loading…