Methyl iodide → (2-Acetyl-4-methylpentyl)trimethylammonium Iodide

HRID 38312

Reaction equation

HRID 38312 reaction equation
[I:1][CH3:2].[CH3:3][N:4]([CH2:6][CH:7]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:8](=[O:10])[CH3:9])[CH3:5]>C(OCC)(=O)C>[I-:1].[C:8]([CH:7]([CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:6][N+:4]([CH3:2])([CH3:5])[CH3:3])(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 534190393-((Dimethylamino)methyl)-5-methyl-2-hexanone

Product 1

HCID 86641883(2-Acetyl-4-methylpentyl)trimethylammonium IodideYield 68.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Iodomethane (20 g, 140.94 mmol, 2.00 equiv) was added dropwise to a solution of 3-((dimethylamino)methyl)-5-methylhexan-2-one (12 g, 70.05 mmol, 1.00 equiv) and ethyl acetate (50 mL). The solution was stirred at ambient temperature for about 16 hours., and the resulting preciptant was collected by filtration to afford the title product (15 g, yield=68%).

Workup

  1. filtration, and the resulting preciptant was collected by filtration

Sources & evidence

ORD record
ord-279e4411a2944fb7abb24634632e5481
Source dataset
uspto-grants-2013_09
Patent number
US08524733B2

Linked notes

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