Ammonia → Tert-butyl(2-cyclohexylethyl)amine

Reaction equation

[CH:1]1([CH2:7][C:8](O)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:11]([NH2:15])([CH3:14])([CH3:13])[CH3:12].N>>[C:11]([NH:15][CH2:8][CH2:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)([CH3:14])([CH3:13])[CH3:12]

Participants

Reactant 3

HCID 222Ammonia

HCID 6385Tert-Butylamine

HCID 21363Cyclohexaneacetic acid

Product 1

HCID 11309910Tert-butyl(2-cyclohexylethyl)amine

Procedure

The desired amine was prepared using the method described in Example 1171A starting with cyclohexylacetic acid and t-butylamine. m/e (DCI/NH3) 184 (MH+)

Sources & evidence

ORD record: ord-4174953b997a4e6e8c6aea6195b70437
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06310095B1

Reaction notes

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