Tetrahydro-4H-pyran-4-ol → 4-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran

HRID 384879

Reaction equation

HRID 384879 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([OH:9])=[C:4]([F:10])[CH:3]=1.[O:11]1[CH2:16][CH2:15][CH:14](O)[CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([O:9][CH:14]2[CH2:15][CH2:16][O:11][CH2:12][CH2:13]2)=[C:4]([F:10])[CH:3]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 27362924-Bromo-2,6-difluorophenol

Product 1

HCID 684092764-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran

Procedure

The title compound was prepared from 4-bromo-2,6-difluorophenol and tetrahydro-4H-pyran-4-ol in analogy to Example 9c): MS (EI): 292 and 294 M+.

Sources & evidence

ORD record
ord-caf70b5253454db490934fa4fd423ba1
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Linked notes

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