Potassium Carbonate → 1-Bromo-2-fluoro-4-(2,2,3,3,3-pentafluoro-propoxy)-benzene

HRID 384892

Reaction equation

HRID 384892 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[F:9].O([CH2:18][C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21])S(C(F)(F)F)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21])=[CH:4][C:3]=1[F:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27760192,2,3,3,3-Pentafluoropropyl trifluoromethanesulfonateHCID 27791534-Bromo-3-fluorophenol

Product 1

HCID 874432981-Bromo-2-fluoro-4-(2,2,3,3,3-pentafluoro-propoxy)-benzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compound was prepared from 4-bromo-3-fluorophenol and 2,2,3,3,3,-pentafluoropropyl triflate with potassium carbonate in acetone at ambient temperature for 18 hours. Kugelrohr distillation provided a colorless oil, b.p. 105-110° C./12 mbar.

Workup

  1. distillationKugelrohr distillation
  2. customprovided a colorless oil, b.p. 105-110° C./12 mbar

Sources & evidence

ORD record
ord-7ef815b8595f4da1b115d094560517b9
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Linked notes

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