Formaldehyde → 3-(3,5-Dichloro-4-methoxybenzoyl)-5-trifluoromethyl-2,3-dihydro-1,3-benzothiazole

2-amino-4-trifluoromethylbenzenethiol hydrochloride (502 mg), and 5-trifluoromethyl-2,3-dihydro-1,3-benzothiazole synthesized from 37% formalin (0.18 mL) and triethylamine (0.30 mL) in the same manner as in Example 38 were dissolved in dichloromethane (5 mL), and triethylamine (0.30 mL) and 3,5-dichloro-4-methoxybenzoyl chloride (354 mg) were added to the solution, and then the mixture was stirred at room temperature for 2 hours. Water was added and the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, 1N sodium hydroxide and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=8:1) to obtain the title compound (223 mg) as a colorless oily substance.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with 1N hydrochloric acid, 1N sodium hydroxide and saturated brine
3. dry with materialdried over anhydrous sodium sulfate
4. distillationThe solvent was distilled off under reduced pressure
5. customthe obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=8:1)

ORD record

ord-d5012945561b40dab83d8844f581d420

Source dataset

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08367843B2