Trifluoroacetic acid → 5-(4-Bromophenyl)-1H-1,2,4-triazole

HRID 385752

Reaction equation

HRID 385752 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12](C(OC(C)(C)C)=O)[CH:11]=[N:10][N:9]=2)=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[CH:11][NH:10][N:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68670520HCID 68670520, compound

Product 1

HCID 469487345-(4-Bromophenyl)-1H-1,2,4-triazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Into a 2000 mL 3-necked flask was placed a solution of tert-butyl 3-(4-bromophenyl)-4H-1,2,4-triazole-4-carboxylate (80.0 g, 247 mmol) in CH2Cl2 (800 mL). To the mixture was added TFA (400 mL). The resulting solution was stirred at room temperature for 1 h. The reaction was evaporated to provide 3-(4-bromophenyl)-1H-1,2,4-triazole as a white solid.

Workup

  1. customInto a 2000 mL 3-necked flask was placed
  2. customThe reaction was evaporated

Sources & evidence

ORD record
ord-dcd341de968f441c99e32ed2b998a0b9
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Linked notes

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